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The Effect of Intravenous Gamma-globulin Reagents on the Measurement Results of (1➔3)-β-D-glucan
Department of Respiratory Medicine and Infectious Disease, Niigata University Graduate School of Medical and Dental Sciences
Hiroshi MORO, Nao KOSHIO, Yuuki BAMBA, Takeshi KOIZUMI, Hiromi CHO, Nobumasa AOKI, Masachika HAYASHI, Chikako TSUBATA, Akiko SAKAGAMI, Mizuho SATO, Takuro SAKAGAMI, Toshiyuki KOYA, Yoshinari TANABE & Toshiaki KIKUCHI
(Received June 7, 2016)
(Accepted September 12, 2016)
Key words: (1→3) β-D-glucan, intravenous immunoglobulin, false-positive

Serum (1→3) beta-D-glucan (BG) measurement is a useful test for systemic mycoses, and often used. On the other hand, various factors, including administration of intravenous immunoglobulins (IVIG) may cause false-positives. In the present study, we measured BG concentration of seven IVIG preparations with three lots respectively. BG levels varied with individual IVIG preparations (<3.0 - >300 pg/mL), and contamination from manufacturing processes was suspected.

With serum BG concentration of clinical specimens obtained in Niigata University Medical & Dental Hospital, the difference between before and after administration of IVIG were calculated.

The false-positive rate of BG due to IVIG administration was 9.8 %, and the positive predective value was reduced to 37.5%. Above all, administration of IVIG can complicate the BG test's interpretation, and caution is required.

[ Kansenshogaku Zasshi 91: 1-6, 2017 ]

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