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Clinical Suspicion of Infant Botulism in a Patient Presenting with Generalized Weakness
1)First Department of Pediatrics, Toho University Omori Medical Center, 2)Department of Clinical Laboratory, Toho University Omori Medical Center
Tomoka SAWA1), Yuki FUJIMAKI1), Yukiko UETA1), Masakazu SASAKI2), Kazuhiro TATEDA2) & Akira OHARA1)
(Received April 24, 2017)
(Accepted September 29, 2017)
Key words: infant botulism, Clostridium botulinum, infant

Infant botulism is characterized by flaccid paralysis caused by the neurotoxin produced by Clostridium botulinum.

We report herein on the case of a 10-month-old girl presenting with decreased activity. There was no history of perinatal or developmental problems. Disturbance of consciousness was suspected on admission. Her clinical manifestations of floppy infant syndrome, poor feeding, and weak cry had progressed over three days prior to admission. Although laboratory test results were normal, respiratory muscle palsy caused respiratory arrest 12 hours after admission. A definitive diagnosis of infant botulism was made when Type A botulinum toxin was detected in her feces.

Infant botulism presents as flaccid paralysis without impaired consciousness. However, it is difficult to exclude coma in patients with flaccid paralysis, particularly in infants.

[ Kansenshogaku Zasshi 92: 65-70, 2018 ]

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