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The Analysis of Invasive Haemophilus influenza Infections During the Past Thirteen Years
1)Department of Infection Prevention and Control, Yokohama City University Medical Center, 2)Department of Laboratory Medicine and Clinical Investigation, Yokohama City University Medical Center, 3)Department of Pharmacy, Yokohama City University Medical Center, 4)Yokohama City Institute of Public Health, 5)Yokohama City University Graduate School of Medicine, Pediatrics
Hiroyuki SHIMIZU1), Saori KIDA2), Yoshifumi SUGIYAMA2), Soichiro SUGIYAMA3), Yuko MATSUMOTO4), Yoshimi OTA4), Jun TSUKIJI1), Eiji MIYAJIMA2) & Shuichi ITO5)
(Received August 22, 2017)
(Accepted December 18, 2017)
Key words: Haemophilus influenzae, vaccine, bacteremia, non-typeable

Since the introduction of the Haemophilus influenzae type b (Hib) conjugated vaccine for infants, the incidence of invasive Hib disease in children has decreased dramatically, while non-typeable and capsulated strains other than serotype b which were not contained in the Hib vaccine were thought to be increasing. We have studied invasive H. influenzae disease of all age group who visited our hospital. A total of 20 patients were included as analysis objects between January 2003 and October 2015. Of the 20 patients, 11 (median age 2 years old, range 13 days-5 years old) were children and 9 (median age 71 years old, range 29-88 years old) were adults. All pediatric cases were documented before 2010, in which the analyzed capsular typing of those were all type b. However 8 of 9 cases of adult patients occurred after 2012 and the capsular typing of these cases was non-typeable H. influenzae (NTHi) (6 cases), type e (1 case) and unknown (2 cases). Infected organs were meningitis (5 cases), pneumoniae (5 cases), epiglottitis (5 cases), cholangitis (3 cases) and intra-uterine infection (1 case). Invasive NTHi infection may have increased after the routine vaccination with the Hib vaccine for infants.

[ Kansenshogaku Zasshi 92: 347-352, 2018 ]

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